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Combination of siltuximab with chemotherapies achieved an impressive ORR of 90.9% in patients with untreated multiple myeloma [353]

We note this is consistent with our proposals to remove this LTCH from the calculation of the FY 2024 MS-LTC-DRG relative weights, the area wage level adjustment budget neutrality factor, and the fixed-loss amount for LTCH PPS standard Federal payment rate cases (discussed in section VII.B.3

In relation to the immune system, glutathione deficiency may impair macrophage and T-cell function 7 in relation to the immune system

18 Overall, ALC was generally well tolerated, with predominantly mild GI and CNS events, and no evidence of excess serious AEs compared with controls