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Thus, NRF2 activates pathways that reduce the toxic insult and restore physiological ROS levels

doi: 10.1021/acs.analchem.6b04727 96 DunnWBBroadhurstDBegleyPZelenaEFrancis-McIntyreSAndersonNet al

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Thus, GPX1 and Bcl-2 display analogous effects on an antioxidative event in the signalling cascade leading to inhibition of apoptosis, although by different mechanisms