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For example, GSTM1 suppresses NLRP3 output by mediating CASP1 SSG, thereby limiting CASP1 activation and downstream pyroptosis in acute keratitis 65

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The Klotho protein is crucial in the functionality of renal tubular epithelial cells, and mice deficient in Klotho exhibit traits associated with aging ( Ink4a pathway can exacerbate cellular senescence, leading to G2/M phase cell cycle arrest