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A deficiency in this vitamin can potentially result in irreversible neurological damage to the growing fetus due to impaired oxygen transport into cells
Epigenetic and Cellular Reprogramming: By blocking NNMT-mediated methylation of nicotinamide, preserves NAD salvage pathway activity, increases SIRT-1 signaling, reduces histone deacetylation, and promotes metabolic reprogramming toward oxidative phosphorylation and glycolysis balance, supporting tissue repair and energy homeostasis 1-4
2 Benditz A, Brunner M, Zeman F, Greimel F, Florian V, Boluki D, Grifka J, Weber M, Renkawitz T
Skin sensitivity: an emerging signal Skin burning and abnormal touch sensitivity (dysesthesia) appears as a dose-related, reversible signal in two case series and post-market surveillance. Trials did not pre-specify it, and the tirzepatide label does not list it