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6.1 Glutathione metabolism: modern view of biosynthetic pathways, NADPH dependence, and relationship to thioredoxin The synthesis of glutathione (GSH) predominantly occurs through the ATP-dependent -glutamyl cycle, beginning with the action of glutamate-cysteine ligase (GCL), the key rate-limiting enzyme composed of two subunits: a catalytic component (GCLC) and a regulatory modifier (GCLM)

A phase of ionic edema is also sometimes referred to as an intermediate between cytotoxic and vasogenic edema, corresponding to the formation of extracellular edema with an undamaged BBB and impermeable BBB to larger molecules such as proteins (70, 71)

Dihexa works through HGF/c-Met allosteric potentiation with structural synaptogenesis as the primary outcomeit has no human clinical trial data and effects in animals required multi-week treatment for full expression

SMAR1-derived P44 peptide retains its tumor suppressor function through modulation of p53