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The researchers noted a significant benefit to the subjects with the parenteral thiamine administration

Causes of small fiber neuropathy include idiopathic (30% of cases no identifiable cause), diabetes and pre-diabetes (impaired glucose tolerance), autoimmune diseases (Sjogrens syndrome, celiac disease, lupus), genetic causes (sodium channel gene mutations SCN9A, SCN10A), and sarcoidosis

Some individuals may experience mild redness or discomfort at the injection site, which typically resolves quickly

Sever AZ, Sever M, Vidovic T, Lojo N, Kolenc D, Vuletic LB, et al

Note that taking other forms of vitamin B, specifically folate or folic acid, may interact with methotrexate (Trexall)