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Each is paired with individual hand-wired 500k volume and tone controls, which, along with a three-way pickup selector toggle switch, provide the wide range of tonal versatility for which the ES-335 is famous

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Through this mechanism, nicotine is thought to increase dopamine levels in the striatum via the mesolimbic pathway, which reduces the dopamine receptor blockade caused by antipsychotics and results in an improvement of extrapyramidal side-effects (Laruelle Reference Laruelle2014)

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