Outcome monitoring should employ validated, condition-specific measures appropriate to the treatment indication
The B12 deficiency itself getting worse, either because not enough unhealthy red blood cells have expired and been replaced by healthy ones (each one of them has a 90 day life-cycle), or because the B12 wasnt injected on a daily schedule
Both intermittent dosing schedules (injections on specific days) and continuous daily administration showed benefits, suggesting some flexibility in protocol design
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We always recommend meticulous planning for combined studies