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N-acetylcysteine and ebselen but not nifedipine protected cerebellar granule neurons against 4-hydroxynonenal-induced neuronal death

This is the theoretical basis for endogenously supplied gamma-glutamylcysteines ability to raise GSH levels, as being the product of the GCL enzyme, it can be taken up by cells intact, where it feeds directly into glutathione synthase to be converted to glutathione, effectively bypassing the dysfunctional GCL

Consequently, there is an unmet need to identify novel treatment strategies to boost the response to neoCRT in rectal cancer patients to facilitate organ preservation and improve outcomes for patients