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This longevity of research interest is itself informative: compounds that fail to replicate across independent laboratories typically disappear from the literature within a decade

With a 5mg vial reconstituted at 2mL (2.5mg/mL), here is how the math works across the full titration: At the starting dose, a single 5mg vial lasts nearly five months

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In fact, studies suggest that when B12 levels drop below a certain threshold, around 253 pg/ml, it can cause changes on an ECG that point to a higher risk for arrhythmias, even in otherwise healthy people