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Study selection was guided by the following PICO-derived questions In individuals with fibromyalgia, does increased oxidative stress or mitochondrial dysfunction (compared to healthy controls) correlate with greater symptom severity and inflammatory biomarkers

doi: 10.1016/j.autrev.2019.102390 222 KotylaPJIslamMAEngelmannM

Furthermore, GDF15 has been implicated in disorders associated with central sensitization, highlighting its relevance to FM pathophysiology 11

Under physiological conditions, ROS are neutralized by endogenous antioxidant systems which include superoxide dismutase (SOD), catalase, and glutathione peroxidase (58)

2012 Apr;107(8):1119-27