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Following iron release, the TF-TFR1 complex is recycled back to the cell membrane via the endosome, which recycles TF and TFR1 ( 2+ can be exported from cells by ferroportin (FPN), a process inhibited by hepcidin, which blocks and ubiquitinates FPN

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Larger injection volumes (12mL) are more forgiving of small measurement errors than tiny volumes (0.30.5mL), where a 0.1mL miscalculation represents a 2033% dose variation