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27 Vertebral body fracture without the involvement of the endplate (type A2), the NP or the AF does not directly affect the disc structure, and, hence, the direct biological consequences may be assumed to be similar to injury type A1

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the recognized involvement of the HGF/c-Met system in the regulation of angiogenesis see reviewsupports the potential utility of HGF/Met antagonists for the treatment of disorders in which control of tissue vascularization would be clinically beneficial