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doi: 10.3390/diseases9010017 150 KryukovE

E2-conjugating enzymes: intermediaries in ubiquitination E2-conjugating enzymes act as intermediaries in the UPS pathway, transferring ubiquitin from E1-activators to substrate proteins, often in collaboration with E3 ligases

Unknown Risks with Prolonged Use: As with any treatment, the long-term effects beyond a decade of continuous use are not fully studied, emphasizing the need for periodic medical evaluations