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Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression

The first step in taking B12 supplements is to consult with a healthcare professional to make sure they are appropriate for your specific requirements

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Stem Cells Transl Med 8:138147