Overconsumption of Omega-6 polyunsaturated fatty acids (PUFAs) versus deficiency of Omega-3 PUFAs in modern-day diets: the disturbing factor for their balanced antagonistic metabolic functions in the human body
Research Progress on the Pharmacological Function of Baicalin
As an excitatory neurotransmitter, high level of glutamate can alter the strength of certain groups of glutamatergic synapses in a variety of brain regions, such as the prefrontal cortex (PFC), hippocampus, and nucleus accumbens (NAc), causing dysfunction of cortico-mesolimbic reward circuitry that underlies many manifestations of depression (52)
This contrasting response is likely due to the suppressive signals generated at high doses, which counteract the regenerative effects mediated by EGFR and c-Met, overwhelming their beneficial impact
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