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found that GF mice lack NKp46 cells that produce IL-22, indicating that intestinal microflora may play a key role in promoting the differentiation of IL-22NKp46 cells [50]
Author contributions UR, OB, GDN, RT, SSal, PS, and PPar conceived and planned this project inviting all the experts in this field from both the Italian Society of Pediatric Gastroenterology Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP), they have also written the first draft of the manuscript
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