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The major cricitism is that one measure (speed/volume of nicotine delivery) may not capture the multiple factors that allows an artificial device to replicate what the smoker can do to individualize and optimize the pattern of nicll convention al cigaretttes vary little in actual ability for a user to extract nicotine in the needed dose, variation of amount during, deposition, an induced reward and treatment of withdrawal

Acknowledgements The authors thank previous task force members Ahmed Abou-Setta, Heather Colquhoun, Roland Grad, Tina Korownyk, Scott Klarenbach, John C

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