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-CAs often exhibit strongly pH-dependent activity in which an Asp is recruited into the open coordination site at high pH, thus abolishing turnover

Imidazoline (I Clonidine is an imidazoline derivative that binds to central imidazoline I 1 ) Receptor Agonism: 1 receptors in the brainstem (including the nucleus tractus solitarii and rostral ventrolateral medulla) with high affinity

Allylamine Allylamines, such as naftifine, butenafine, and terbinafine, inhibit a flavine adenine dinucleotide dependent enzyme, squalene epoxidase (EC 1.14.99.7) [171], responsible for converting squalene to squalene-2,3-epoxide, an intermediate in the biosynthesis of lanosterol [163, 172]