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10.1016/j.pain.2014.04.022 Pain 69 KokkinouM.AshokA

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Generally, HO-1 levels remain low across diverse tissues except for the spleen, but diverse stimuli (like hydrogen peroxide, UV radiation, endotoxins, and hypoxia) can cause a strong inducible response for shielding cells from damaging oxidative and inflammatory agents [34]

For an injury protocol, a separate TB-4/TB-500 bolus may be placed near an accessible injury when the protocol calls for it, but the GLOW premix remains the background layer