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Mechanism of Action: Octopamine replaces norepinephrine in sympathetic neurons with chronic use of monoamine oxidase inhibitors Dopamine beta-hydroxylase converts tyramine to octopamine Octopamine can be taken up into storage vesicles in nerve terminals, and then be released by nerve stimulation Octopamine exerts only a small effect on postsynaptic receptors compared to norepinephrine (hence the designation false transmitter) Notes: Octopamine typically exists in only trace amounts in the mammalian CNS, but accumulates when MAO is inhibited (e.g
Irfan HM, Asmawi MZ, Khan NA, Sadikun A, Mordi MN
*Prozentsatz der Nhrstoffbezugswerte gem
Drug Metab Dispos 31:14991506 James LP, Letzig L, Simpson PM, Capparelli E, Roberts DW, Hinson JA, Davern TJ, Lee WM (2009) Pharmacokinetics of acetaminophen-protein adducts in adults with acetaminophen overdose and acute liver failure