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Researchers who rush the escalation tend to experience more severe nausea, which can lead to skipped doses, inconsistent protocols, and ultimately worse outcomes

For musculoskeletal or systemic targets, injections are the better-supported route based on existing animal data

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Representative tissue specimens were embedded in paraffin, sectioned at 4 m, stained with hematoxylin and eosin (H&E), and evaluated by light microscopy using an Olympus 71 digital camera and an Olympus BX51 microscope (Japan) acquiring digital images saved as uncompressed 24-bit RGB TIFF files