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It can result from elevated estrogen production (excess adipose aromatase activity), reduced estrogen clearance (impaired hepatic Phase I or Phase II metabolism), low SHBG (leaving more biologically active free estrogen), xenoestrogen exposure, or progesterone insufficiency

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And if you're just breaking down, you're getting bad structures, so you're doing both

It also plays crucial roles in the immune response, DNA repair, mitochondrial function and the detoxification of drugs, chemicals, heavy metals, radiation, metabolic wastes, and other toxins and carcinogens

Biomaterials 30, 30503057 (2009)