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Finally, the ADME optimization of the drug can be useful in some ways to further substantiate its hypothetical efficacy and safety

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Sorafenib has the capability to inhibit ferroptosis in HCC through the activation of NRF2 and Rb, among others [120]

alteration in hormones including serotonin, histamine, prostaglandins and cytokines

Once synthesized, GSH serves as a substrate for GSH peroxidases (GPx), which reduce hydrogen peroxide and lipid peroxides into water and lipid alcohols, respectively (Lu, 2013)