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In the first step of the cycle, acetyl CoA condenses with oxaloacetate to yield citrate and succinyl-CoA providing energy for GDP phosphorylation

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Traditional Chinese medicine formulations, such as Simiao Pills, demonstrate multi-component synergy (phenolic acids, terpenoids, and alkaloids) in mitigating hyperuricemia and renal injury, mediated through anti-inflammatory effects and renal transporter modulation (Zeng et al., 2024)

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