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Review the foundational preclinical research concerning selective small-molecule NNMT inhibitors

Endothelial dysfunction has been demonstrated in vivo (306, 311), in the large vessels of ME/CFS patients (307, 311) through flow-mediated dilation (FMD) and in the microcirculation through post-occlusive reactive hyperaemia

This makes it convenient when one needs to mix a multi-dose medication (for example, reconstituting a vial of medication that will be used for several injections over a course of days)

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