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Akamine H, Takasu N, Komiya I, Ishikawa K, Shinjyo T, Nakachi K, et al

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A main effect of age, irrespective of group, was observed for brain weight, with higher values in aged animals (Table 2)

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Epigenetically, Epitalon modulates histone H1 binding and chromatin condensation in models of replicative senescence, consistent with a role in maintaining heterochromatin architecture at telomeres and pericentromeric repeats a chromatin structure known to deteriorate with age