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Dihexa(PNB-0408), an oligopeptide drug, is an orally active and blood-brain barrier-permeable analog of angiotensin IV

C408 sits behind a positively charged wall formed largely by the side chains of R370 and R413

Instead of whitening, the result is a healthier, more radiant tone, and the skin becomes lighter and brighter

The resuspended bacteria were lysed by ultrasonication on ice (four 5-min sessions with 30% amplitude, 2.0 s pulse on, 2.0 s pulse off, interspersed with 1-min pauses)