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We do not know whether IGF-1 clearance changes in the presence of triple-receptor activation

This truncated soluble receptor inhibited the autophosphorylation of the endogenous IGF-1R as well as induced extensive apoptosis in vivo and inhibited tumorigenesis in syngeneic rats

Trends in molecular medicine 21 , 193201, doi: 10.1016/j.molmed.2014.11.008 (2015)

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