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However, the evidence remains inconclusive, and more robust randomized controlled trials (RCTs) are needed to establish a definitive causal relationship

Wang et al., 2020

This spatial difference (matrix vs

In SURMOUNT-1 , a 72-week Phase 3 double-blind trial in 2,539 adults with obesity (or overweight with a complication) but without diabetes, once-weekly tirzepatide produced mean weight changes of 15.0% (5 mg), 19.5% (10 mg), and 20.9% (15 mg) versus 3.1% with placebo, with 5057% of participants on the higher doses losing at least 20% of body weight

Reduced prefrontal glutamate/glutamine and -aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy