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Thus, it can be deduced that RAGE can bind the ligands stimulated by CS and further promote the expression of IL-33, then coordinate a series of inflammatory responses downstream of IL-33 to aggravate the airway damage in patients with asthma, which results in the airway remodeling aggravated finally 5,74,75

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Indeed, e-cigarettes containing nicotine may relieve the craving for smoking, but not the conventional cigarette smoking habit