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Most of the affected patients reported using products containing THC, the main psychoactive compound in marijuana

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Concerning CYP1A2, in vivo induction is suggested, as demonstrated by the paraxanthine-to-caffeine ratio rising in healthy subjects ( In light of these findings, the safety and efficacy profile of RIF during TB treatment can be altered in smokers because of the concomitant induction of CYP450 enzymes mediated by PAHs