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The authors were able to rule out a gateway effect from e-cigarette use to smoking uptake of the size commonly reported in the literature but were not able to rule out very small effects for a gateway in or out of smoking (where e-cigarette use makes it less likely that young people start to smoke)

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B & C) The metathoracic bars in the prepupal stage are highlighted by the black boxes

THC mimics these natural compounds but binds much more powerfully to CB1 receptors