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Supplementary Material Abbreviations Used %RSD percent relative standard deviation ACN acetonitrile CBD cannabidiol DAD diode array detection DEA Drug Enforcement Agency DNPH 2,4-dinitrophenylhydrazine EDDS electronic drug-delivery systems FDA Food & Drug Administration HCI Health Canada Intense HPHC harmful and potentially harmful constituent HPLC high performance liquid chromatography LLOD lower limit of detection LLOQ lower limit of quantification m slope QC quality control R 2 coefficient of determination SCSM-STEP single cigarette smoking machine SD standard deviation S y standard deviation of the response THC 9 -tetrahydrocannabinol THF tetrahydrofuran Author Disclosure Statement J.O.E

Absorption : The total nicotine absorbed is highly dependent on how long the pouch is held in place, the pH level of the pouch (which affects bioavailability), and the users saliva production

How is it diagnosed

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on the main board of the JSE in South Africa, the Group is required to present headline earnings per share and diluted headline earnings per share, as alternative measures of earnings per share, calculated in accordance with Circular 1/2023 Headline Earnings issued by the South African Institute of Chartered Accountants