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When scientists looked at the lung tissue of some people who smoke marijuana regularly, they found changes that are known to signal the future growth of cancer

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In a later study, Witschi and colleagues (2004) used a similar exposure regimen with five months of whole-body exposure to smoke from 2R4F reference cigarettes (89-percent sidestream and 11-percent mainstream smoke), followed by a four-month recovery period

In answer to the more direct question of how much nicotine per day is safe, a reasonable starting point might be, "How much nicotine might it take to poison someone?" The ECHA currently gives an "acute toxicity estimate" (ATE) for nicotine via the oral route to be 5 mg/kg bw [7] , meaning 5mg of nicotine for every kilogram of bodyweight of the person consuming the nicotine