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An orally available NNMT inhibitor if the animal bioavailability data translates to humans would have significant practical advantages

By blocking NNMT activity, 5-amino-1MQ preserves intracellular NAD+ availability, which activates sirtuins and the AMPK pathway

Current evidence suggests: its primary target is NNMT metabolism rather than endocrine hormone receptors

Additionally, Parasutterella relative abundance, which was increased in both the vehicle- and NNMTi-treated LD-switched groups relative to the controls, significantly correlated with several adipose tissue metabolites abundances

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