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Reducing Cholesterol Synthesis or Promoting Cholesterol Efflux in Airway Epithelial Cells Protects Against Cigarette Smoke Extract-Induced Inflammation To further investigate whether changes in intracellular cholesterol levels contribute to the development of cigarette smoke-induced airway inflammation, we silenced the expression of cholesterol biosynthesis-related molecules SREBP2 and HMGCR in HBE cells using siRNA (Figure 3A and B) and inhibited cholesterol biosynthesis in HBE cells using the inhibitor lovastatin (Figure 3F and G)
- 'Died with Yugoslavia' -The declaration has sparked debate and criticism across the Balkans, where political tensions have risen in recent months and not everyone wants to emphasise linguistic similarities."That common language was a political project which died along with the former Yugoslavia," said Croatian President Kolinda Grabar-Kitarovic.But Croatian satirist and writer Ante Tomic drily noted that the president had little difficulty communicating in the language with regional politicians.Although the concept of a common language seems to be better accepted in Serbia, Milos Kovacic of the Serbian Literary Association argued it had not been named "since everyone knows well that it is the Serbian language".Snjezana Kordic, a Croatian linguist and initiator of the declaration, described it as a "typical example of a polycentric standard language, spoken by several peoples, containing differences from which one can recognise where a speaker comes from".She compared it with variants of English, French or German.Although the declaration has won support from 8,000 people so far, critics have slammed them as traitors of their respective countries.Croatian writer Davor Velnic described the signatories as "Yugo-intellectuals" and "parasites" who "never accepted the fact that there is an internationally-recognised sovereign Croatian state".
Increased spending on tobacco control efforts accompanied by raising cigarette taxes can be a powerful combination in reducing smoking rates
The same is true of tobacco farmers in North Carolina
