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e , HCC-1806 cells were grown in control media alone or supplemented with GSH (750 M) and treated with DMSO or CB-839 (5 M) for 72 h, and relative cell numbers were determined (n = 12 technical replicates from 3 independent experiments

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Antagonists: Improper activation of the c-Met receptor can be encouraged by genetic activating mutations, transcriptional upregulation or by ligand-dependent autocrine or paracrine mechanisms