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Several key genes in iron metabolism that regulate ferroptosis were identified, including transferrin and SLC39A14 iron transporters (112), the heavy chain of ferritin (FTH1) (113, 114), as well as TFR1 (115), FPN1 (116, 117), PCBP1 (118), and NCOA4 (119)all reported to modulate ferroptosis through iron homeostasis

Effect of sleep hygiene training given to elderly individuals on daytime sleepiness and fatigue: A randomized controlled trial

Nat Commun 14:6502

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A key future direction involves defining optimal drug ratios and identifying predictive biomarkers to guide patient selection for such metabolically targeted combination therapies