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9 Protein binding of NAPQI occurs predominantly in centrilobular hepatocytes, which eventually undergo oxidative stress, mitochondrial dysfunction, and necrotic cell death

Recent studies have shown that autistic disorder is likely to involve multiple genes [79] although a common genetic change is not seen in all cases suggesting that it is likely to be a cluster of conditions, each with its own individual and yet overlapping pathology

The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore

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Additionally, ROS can influence the differentiation and function of T cells, promoting the polarization of T helper 17 (Th17) cells, which are known to play a pathogenic role in autoimmune diseases such as multiple sclerosis (MS) and psoriasis [136]