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Int J Oral Maxillofac Surg 2009

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3,4,5 The studies reviewed here in the cigarette smokers of the Multiethnic Cohort Study (MEC), a large contemporary prospective epidemiologic study, use biomarkers of exposure and metabolism of nicotine, NNK, polycyclic aromatic hydrocarbons (PAH) and other volatile carcinogens to investigate the mechanism underlying the ethnic/racial differences in lung cancer risk