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Many antioxidant responses are controlled by the Nrf2, an evolutionary conserved transcription factor that is sequestered under basal conditions but upregulated acutely during oxidant attack

Arjmand et al., 2022

Considering that curcumin is nontoxic, readily available and inexpensive, it is a prospective candidate for treating heart diseases

CD8(+) T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy

This mechanism naturally limits absorption when B12 is consumed in large quantities, with excess amounts typically eliminated through the kidneys without causing harm