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28 Fourth, while this study provides insight into GPR15-associated modulation of T-cell populations, the precise molecular mechanisms underlying GPR15-dependent immune regulation remain incompletely understood, especially regarding its effects on Treg-to-Th1 differentiation and Th17 cell stability in the context of cigarette smoke exposure, warranting further investigation

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It clearly separates the short-term biochemical effects of nicotine from the long-term harm of smoking, which is where many misconceptions arise

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