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Through Y maze, new object recognition and radial arm maze assessment, nicotine metabolites cotinine and 6-hydroxy-L-nicotine, also showed cognitive improvement effects, positively regulating the expression of brain-derived neurotrophic factor (BDNF), neuronal specificity and postsynaptic memory consolidation related protein (arc) and proinflammatory factor interleukin one beta (IL-1) in Alzheimers rats induced by A, exhibiting higher affinity with 42 nAChR and 7 compared to nicotine