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Ejaz, U., Sohail, M., & Ghanemi, A

MOTS-c activates AMPK (AMP-activated protein kinase), which signals cells to shift from glucose storage to fat oxidation and improves insulin sensitivity through mitochondrial and nuclear gene regulation

Internal states of the Nrf2-Keap1 complex support the hinge-latch hypothesis In the current literature the hinge-latch hypothesis is the leading hypothesis with much evidence pointing in that direction 2,3,23,34