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Spitz FR, Kataoka M, Sarkiss M, Meyn R, McDonnell TJ, Swisher S , Cristiano RJ, Roth JA

A novel air exposure model in C57BL/6 mice, utilizing endotracheal drip, revealed that inhaled MPs promote M1 polarization of microglia through the lung-brain axis, subsequently leading to cognitive impairments in mice (Yang et al., 2024)

2.2.3 Key regulatory networks The tumor suppressor p53 can transcriptionally repress SLC7A11 expression, diminishing cystine uptake, curtailing GSH synthesis, and thereby promoting ferroptosis ( Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating redox homeostasis

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