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Karama S, Bastin ME, Murray C, Royle NA, Penke L, Munoz Maniega S et al

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However, disease relapse occurs in most patients, probably due to the selection for surviving treatment insensitive malignant cells, possibly so-called cancer stem cells [138]

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Under conditions of cellular homeostasis, the stability and function of p53 protein are controlled by MDM2 that targets p53 for degradation and directly inhibits p53 activity by binding to the transcriptional activation domain 17