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Human Mol Genet (2007) 16(2):14253.10.1093/hmg/ddl450 66 GelernterJYuYWeissRBradyKPanhuysenCYangB-Zet alHaplotype spanning TTC12 and ANNKK1, flanked by the DRD2 and NCAM1 loci, is strongly associated to nicotine dependence in two distinct American populations

Dopamine is associated with feelings of happiness and ecstasy and, after a while, smokers crave dopamine release that is associated with smoking tobacco and with nicotine

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Rice paper may even be harder to smoke because it is prone to tears, so it is preferred mostly by seasoned smokers