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doi:10.1186/1471-2458-7-159

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Why Nicotine May Make You Feel Sick If nicotine makes you feel sick, your body could be reacting to one or more of the following mechanisms: Overstimulation of the Nervous System: Nicotine stimulates the release of adrenaline, which can increase heart rate, raise blood pressure, and give you that wired feeling

References (Trusted, Practical Sources) U.S

The nicotine enters your bloodstream through your nose or mouth lining dependent on the type of spray you use