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Alternative products such as e-cigarettes and heated tobacco products have gained increasing market share in recent years 44,45 complicating any estimates of smoking-related burden, as their long-term health risks for exclusive and dual users are still unclear

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[107] Genotoxicity [edit source] Nicotine causes DNA damage in several types of human cells as judged by assays for genotoxicity such as the comet assay, cytokinesis-block micronucleus test and chromosome aberrations test